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GC×GC temperature programming requirements to produce bilinear data for chemometric analysis
Author(s) -
Johnson Kevin J.,
Prazen Bryan J.,
Olund Roy K.,
Synovec Robert E.
Publication year - 2002
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/1615-9314(20020401)25:5/6<297::aid-jssc297>3.0.co;2-i
Subject(s) - chemistry , chromatography , bilinear interpolation , gas chromatography , chemometrics , extraction (chemistry) , analytical chemistry (journal) , column (typography) , computer science , computer vision , telecommunications , frame (networking)
A diaphragm valve‐based comprehensive two‐dimensional gas chromatography (GC×GC) instrument with the two columns under independent temperature control is demonstrated. A fifteen‐component mixture of alkanes, alkyl aromatics, ketones, and alcohols was separated using this system in only 45 s. Independent temperature control of the two columns allows for high‐speed analysis of complex samples while retaining the bilinear data structure that is necessary to apply many chemometric peak‐resolving methods. An important part of high‐speed GC×GC is sharp injections onto the second column. In this work, 10‐ms peak widths on the second column are demonstrated. A peak capacity per time of 240 peaks/min was readily achieved. This work is aimed at providing a high‐speed GC system for the quantitative and qualitative analysis of complex process streams, such as natural products.