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Optimization and characterization of comprehensive two‐dimensional gas chromatography with time‐of‐flight mass spectrometric detection (GC×GC–TOF MS)
Author(s) -
Dallüge Jens,
Vreuls René J. J.,
Beens Jan,
Brinkman Udo A. Th.
Publication year - 2002
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/1615-9314(20020301)25:4<201::aid-jssc201>3.0.co;2-b
The influence of modulator temperature, modulation frequency, temperature programming rate, and carrier gas velocity on the performance of comprehensive two‐dimensional gas chromatography coupled to time‐of‐flight mass spectrometry (GC×GC–TOF MS) was studied. The system was characterized with respect to the repeatability of peak areas and retention times of selected analytes, their detection limits, and the linearity of their calibration plots. The system was found to be linear in the 0.01–3 ng range, and detection limits for the pesticides were between 5 and 23 pg. The performance of the system was compared with that of conventional one‐dimensional (1D) GC–TOF MS, the advantages of TOF MS for identification and deconvolution are discussed, and several approaches for the processing of GC×GC–TOF MS data are explained with the emphasis on (semi)‐automated data processing and the differences with 1D‐GC–TOF MS.