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Quantitative determination of straight and cyclic hydrocarbons in crystallized permethylated‐β‐cyclodextrin inclusion complexes by static headspace‐gas chromatography
Author(s) -
Cardinaël Pascal,
PeulonAgasse Valérie,
Coquerel Gérard,
Combret Yvette,
Combret Jean Claude
Publication year - 2001
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/1615-9314(20010201)24:2<109::aid-jssc109>3.0.co;2-t
Subject(s) - chemistry , methylcyclohexane , pentane , stoichiometry , gas chromatography , cyclohexane , solvent , chromatography , alkane , hexane , extraction (chemistry) , cyclodextrin , toluene , analytical chemistry (journal) , organic chemistry , hydrocarbon
Static headspace‐gas chromatography (HS‐GC) method is used for determination of the stoichiometry of crystalline inclusion complexes of heptakis (2,3,6‐tri‐ O ‐methyl)‐β‐cyclodextrin (TRIMEB) with methylcyclohexane, pentane, cyclohexane, hexane, (–)‐α‐pinene, and (±)‐α‐pinene. The ‘Full Evaporation Technique’ (FET) with Multiple Headspace Extraction (MHE) measurements is realized in a straightforward manner on the solid material; this appears to be the most convenient method for quantitative determination of the guest/host ratio. As an interesting alternative, the ‘solution approach’ (sample dissolved in the solvent) is also performed by a single extraction with ethanol as solvent, which is sufficiently polar to dissociate these complexes. TRIMEB forms stable 1 : 1 complexes with cycloalkanes or cycloalkenes at room temperature and normal pressure. In contrast, the stoichiometry with n ‐alkane is different from ratio of 1 : 1 because this solid shows efflorescent behavior under the same conditions.