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A Practical Recycle of a Ligand‐Free Palladium Catalyst for Heck Reactions
Author(s) -
de Vries André H. M.,
Parlevliet Floris J.,
Schmiedervan de Vondervoort Lizette,
Mommers John H. M.,
Henderickx Huub J. W.,
Walet Monique A. M.,
de Vries Johannes G.
Publication year - 2002
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(200210)344:9<996::aid-adsc996>3.0.co;2-j
Subject(s) - chemistry , palladium , catalysis , heck reaction , ligand (biochemistry) , aryl , catalytic cycle , filtration (mathematics) , bromine , organic chemistry , combinatorial chemistry , alkyl , statistics , mathematics , biochemistry , receptor
Ligand‐free palladium can be recovered almost quantitatively from Heck reaction mixtures by filtration after its deposition on a carrier such as silica or celite. Subsequently, it is re‐activated to its original activity by adding a small amount of iodine or bromine prior to the next reaction cycle. The catalyst results in excellent yields and selectivities, even for the less reactive aryl bromides. A catalytic cycle based on anionic palladium intermediates is proposed.