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Catalytic Asymmetric Mannich‐Type Reactions Using a Novel Chiral Iron Complex
Author(s) -
Yamashita Yasuhiro,
Ueno Masaharu,
Kuriyama Yokusu,
Kobayashi Shū
Publication year - 2002
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(200210)344:9<929::aid-adsc929>3.0.co;2-z
Subject(s) - chemistry , catalysis , yield (engineering) , methanol , ligand (biochemistry) , mannich reaction , derivative (finance) , enantioselective synthesis , chiral ligand , combinatorial chemistry , chloride , organic chemistry , biochemistry , materials science , receptor , economics , financial economics , metallurgy
Catalytic asymmetric Mannich‐type reactions using a novel chiral iron complex have been developed. The reactions proceeded smoothly in the presence of a catalyst prepared from iron(II) chloride, a BINOL derivative, and i ‐Pr 2 NEt. The desired products were obtained in good yield with good to high enantioselectivity, when 3,3′‐I 2 BINOL was employed as a chiral ligand. A protic additive such as methanol facilitated the reactions effectively.