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Applications of Olefin Cross Metathesis to Commercial Products
Author(s) -
Pederson Richard L.,
Fellows Ingrid M.,
Ung Thay A.,
Ishihara Hiroki,
Hajela Sharad P.
Publication year - 2002
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(200208)344:6/7<728::aid-adsc728>3.0.co;2-4
Subject(s) - ruthenium , chemistry , metathesis , olefin metathesis , catalysis , organic chemistry , salt metathesis reaction , combinatorial chemistry , polymerization , polymer
In this paper, we will demonstrate the value of olefin cross metathesis as an effective synthetic tool for applications in the agrochemical and pharmaceutical industries. First, we will demonstrate the usefulness of cross metathesis reactions in the efficient synthesis of the major component of the Peach Twig Borer pheromone and the of Omnivorous Leafroller pheromone, insect pheromones are environmentally friendly pest‐controlling agents. Second, we will demonstrate highly efficient cross metathesis routes into novel α,β‐unsaturated carbonyl intermediates. These novel α,β‐unsaturated carbonyl intermediates can be further functionalized into pharmaceutical compounds that are difficult to prepare by the traditional synthetic methodologies. This paper highlights key catalyst‐substrate reactivity variations with different ruthenium olefin metathesis catalysts, highlights cross metathesis reactions and techniques and highlights an efficient ruthenium catalyst removal technique.