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Chiral Metallosalen Complexes: Structures and Catalyst Tuning for Asymmetric Epoxidation and Cyclopropanation
Author(s) -
Katsuki Tsutomu
Publication year - 2002
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(200202)344:2<131::aid-adsc131>3.0.co;2-t
Subject(s) - cyclopropanation , chemistry , catalysis , ligand (biochemistry) , carbene , combinatorial chemistry , enantioselective synthesis , metal , reaction conditions , organic chemistry , biochemistry , receptor
Optically active metallosalens are currently one of the most widely used catalysts for asymmetric synthesis. This is mainly due to the following reasons: various salen [ N,N′ ‐ethylenebis(salicyldeneaminato)] ligands form complexes with many metal ions and the resulting metallosalens adopt versatile structures, therefore, metallosalens show a variety of catalytic performances. Thus, selection of a metal ion serving the aimed reaction and regulation of ligand conformation to be suitable for the reaction are indispensable for achieving metallosalen‐catalyzed asymmetric reactions. Recently, several factors controlling ligand‐conformation in metallosalens have been clarified. This article provides selected examples of tuning the structures of metallosalens in compliance to the aimed reaction, by taking asymmetric oxene or carbene transfer reaction as the instance.