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Chemical‐Enzymatic Synthesis of Iminocyclitol Phosphonic Acids
Author(s) -
Mitchell Michael,
Qaio Lei,
Wong ChiHuey
Publication year - 2001
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(200108)343:6/7<596::aid-adsc596>3.0.co;2-v
Subject(s) - chemistry , synthon , moiety , enzyme , glycosyltransferase , fructose , phosphate , organic chemistry , chemical synthesis , biochemistry , stereochemistry , combinatorial chemistry , in vitro
Fuculose 1‐phosphate and fructose‐diphosphate aldolases were employed in the chemoenzymatic synthesis of the iminocyclitols 1 and 2 possessing a phosphonic acid moiety. These compounds are useful as core synthons for the development of specific glycosyltransferase inhibitors.