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Advances in Antibody Catalysis of Cycloaddition Reactions
Author(s) -
Tremblay Martin R.,
Dickerson, Tobin J.,
Janda Kim D.
Publication year - 2001
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(200108)343:6/7<577::aid-adsc577>3.0.co;2-z
Subject(s) - cycloaddition , chemistry , stereocenter , catalysis , organic reaction , pericyclic reaction , 1,3 dipolar cycloaddition , organic chemistry , combinatorial chemistry , enantioselective synthesis
Pericyclic cycloaddition reactions are among the most useful transformations available to the synthetic organic chemist. All are capable of simultaneously establishing multiple stereogenic centers with high levels of selectivity. Although many powerful chemical catalysts for these reactions exist, biological catalysts for these reactions are rare, and in most cases, non‐existent. With the advent of catalytic antibody technology, proteins have been developed that are capable of not only catalyzing the Diels−Alder reaction, but also hetero‐Diels−Alder, retro‐Diels−Alder, and 1,3‐dipolar cycloaddition reactions. This review will summarize the key developments in the use of catalytic antibodies as catalysts for these powerful cycloaddition reactions. 1 Introduction 2 Diels−Alder Cycloaddition Reactions 3 Hetero‐Diels−Alder Cycloaddition Reactions 4 Retro‐Diels−Alder Cycloaddition Reactions 5 1,3‐Dipolar Cycloaddition Reactions 6 Concluding Remarks