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Biocatalysis in Polymer‐Supported Synthesis: Enzyme‐Labile Linker Groups
Author(s) -
Reents Reinhard,
Jeyaraj Duraiswamy A.,
Waldmann Herbert
Publication year - 2001
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(200108)343:6/7<501::aid-adsc501>3.0.co;2-d
Subject(s) - chemistry , biocatalysis , linker , yield (engineering) , combinatorial chemistry , cleavage (geology) , enzyme , polymer , organic chemistry , nanotechnology , catalysis , reaction mechanism , computer science , materials science , geotechnical engineering , fracture (geology) , engineering , metallurgy , operating system
The development of new and broadly applicable linker groups which are stable under a variety of reaction conditions and allow release of the desired products from polymeric supports under very mild conditions is of great interest for organic synthesis and combinatorial chemistry. In this review we summarize the results of the research activities directed towards the introduction of enzyme‐labile linkers which yield a variety of different target molecules through enzymatic cleavage from different polymeric supports. 1 Introduction 2 Endo ‐Linkers 3 Exo ‐Linkers 4 Conclusion and Outlook