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A New Enantioselective Synthesis of Milnacipran and an Analogue by Catalytic Asymmetric Cyclopropanation
Author(s) -
Doyle Michael P.,
Hu Wenhao
Publication year - 2001
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(20010330)343:3<299::aid-adsc299>3.0.co;2-y
Subject(s) - enantioselective synthesis , cyclopropanation , chemistry , milnacipran , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , receptor , serotonin
Milnacipran and analogues are conveniently prepared by a short sequence of steps from phenylacetic acid, the key step being highly enantioselective catalytic asymmetric cyclopropanation.