Premium
New Chiral Diphosphine Ligands Designed to have a Narrow Dihedral Angle in the Biaryl Backbone
Author(s) -
Saito Takao,
Yokozawa Tohru,
Ishizaki Takero,
Moroi Takashi,
Sayo Noboru,
Miura Takashi,
Kumobayashi Hidenori
Publication year - 2001
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/1615-4169(20010330)343:3<264::aid-adsc264>3.0.co;2-t
Subject(s) - dihedral angle , chemistry , binap , catalysis , asymmetric hydrogenation , enantioselective synthesis , optically active , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , molecule , hydrogen bond
A series of novel optically active diphosphine ligands, (4,4′‐bi‐1,3‐benzodioxole)‐5,5′‐diylbis(diarylphosphine)s ( 6 ), which are called SEGPHOS, has been designed and synthesized with dihedral angles in the Ru complexes being less than that in the corresponding BINAP‐Ru complex. The stereorecognition abilities of SEGPHOS‐Ru complex catalysts in the asymmetric catalytic hydrogenation of a wide variety of carbonyl compounds are superior to those observed with BINAP‐Ru complex catalysts.