Premium
Muscle paralysis produced by botulinum toxin type A injection in treated torticollis patients compared with toxin naive individuals
Author(s) -
Sloop R. Richard,
Cole Dorothee,
Patel Milan C.
Publication year - 2001
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200101)16:1<100::aid-mds1021>3.0.co;2-g
Subject(s) - torticollis , paralysis , medicine , botulinum toxin , anesthesia , toxin , muscle weakness , weakness , spasmodic torticollis , neurological disorder , central nervous system disease , surgery , biology , biochemistry
We sought to determine whether the response to varying doses of botulinum toxin type A (BTX‐A) injected in BTX‐A‐treated torticollis patients differed from the same injections given in toxin‐naive individuals. We have developed a technique to objectively measure muscle weakness resulting from BTX injections in humans and have validated the technique in those not previously treated with BTX. We now examine BTX‐A‐treated torticollis patients to see if their response to BTX‐A injection is similar to that of toxin‐naive individuals. We injected 11 torticollis patients who had been receiving BTX‐A injections with a standard 5‐mouse unit (mu) dose into one extensor digitorum brevis (EDB) muscle and a varying dose into the other EDB, measuring muscle paralysis 2 weeks after the injection. Nine of the 11 patients were clinical and electrophysiologic responders. Two patients were non‐responders. In the 9 responding patients the dose response curve to increasing doses of BTX‐A was very similar to that seen in toxin‐naive individuals. The mean muscle paralysis from the standard 5 mu dose was also similar to that previously reported in toxin‐naive individuals. Torticollis patients who continue to respond clinically to BTX‐A injections demonstrate essentially the same degree of muscle paralysis from the EDB injections as do subjects who have never been exposed to BTX‐A. Mov. Disord. 16:100–105, 2001. © 2001 Movement Disorder Society.