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Abnormalities of motor cortical excitability are not correlated with clinical features in atypical parkinsonism
Author(s) -
Marchese Roberta,
Trompetto Carlo,
Buccolieri Alessandro,
Abbruzzese Giovanni
Publication year - 2000
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200011)15:6<1210::aid-mds1022>3.0.co;2-r
Subject(s) - parkinsonism , transcranial magnetic stimulation , neuroscience , psychology , parkinson's disease , pathophysiology , degenerative disease , central nervous system disease , levodopa , motor cortex , medicine , disease , stimulation
OBJECTIVE To evaluate the specificity of motor cortical excitability changes in parkinsonian syndromes and their relevance to the pathophysiology of cardinal parkinsonian features. METHODS Paired transcranial magnetic stimulation (TMS) was used to assess cortico‐cortical inhibition (CCI) and facilitation (CCF) in the opponens pollicis muscle of patients with atypical, non‐ L ‐dopa‐ (LD) responsive parkinsonism. RESULTS Compared with age‐matched normal control subjects, CCI (interstimulus interval [ISI], 3 ms) was significantly reduced in 10 patients with predominantly parkinsonian multiple system atrophy (MSA‐P) and in seven with vascular parkinsonism (VP), but not in four with predominantly cerebellar MSA. No significant change of CCF (ISI, 12 ms) was observed. No correlation was found between the amount of CCI and clinical status as evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS). In 10 patients (5 MSA‐P, 5 VP), CCI was significantly increased by LD acute administration without concurrent clinical changes. CONCLUSIONS Abnormalities of CCI are not peculiar to idiopathic Parkinson's disease and seem unlikely to underlie any specific parkinsonian feature, but rather possibly reflect a nonspecific imbalance of inhibitory and facilitatory motor cortical circuits.