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5‐HT 2C receptor binding is increased in the substantia nigra pars reticulata in Parkinson's disease
Author(s) -
Fox Susan H.,
Brotchie Jonathan M.
Publication year - 2000
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200011)15:6<1064::aid-mds1002>3.0.co;2-c
Subject(s) - substantia nigra , basal ganglia , parkinson's disease , globus pallidus , dyskinesia , neuroscience , 5 ht2c receptor , dopamine , medicine , endocrinology , biology , disease , receptor , central nervous system , 5 ht receptor , serotonin
The involvement of abnormalities in nondopaminergic transmitter systems in Parkinson's disease is noteworthy because of the complications, such as dyskinesia, associated with long‐term dopamine replacement therapy. The output regions of the basal ganglia, the substantia nigra pars reticulata, and the medial segment of the globus pallidus are overactive in Parkinson's disease but underactive in dyskinesia. 5‐HT 2C receptors are localized in these regions and are excitatory. A 5‐HT 2C receptor binding assay using [ 3 H]‐mesulergine and SB 200646A to define nonspecific binding was applied to postmortem tissue from patients with Parkinson's disease and from age‐matched control patients. [ 3 H]‐mesulergine binding was increased in the substantia nigra pars reticulata by 108% in Parkinson's disease tissue as compared with control tissue. These data suggest abnormalities of 5‐HT 2C transmission in the basal ganglia of patients with Parkinson's disease.