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Deficit of brain and skeletal muscle bioenergetics in progressive supranuclear palsy shown in vivo by phosphorus magnetic resonance spectroscopy
Author(s) -
Martinelli P.,
Scaglione C.,
Lodi R.,
Iotti S.,
Barbiroli B.
Publication year - 2000
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200009)15:5<889::aid-mds1020>3.0.co;2-t
Subject(s) - phosphocreatine , progressive supranuclear palsy , bioenergetics , in vivo , phosphomonoesters , high energy phosphate , skeletal muscle , medicine , endocrinology , nuclear magnetic resonance spectroscopy , magnetic resonance imaging , chemistry , energy metabolism , biochemistry , biology , atrophy , microbiology and biotechnology , organic chemistry , radiology , mitochondrion
Brain and muscle energy metabolism was assessed in vivo in five patients with progressive supranuclear palsy (PSP) using phosphorous magnetic resonance spectroscopy ( 31 P MRS). 31 P MRS disclosed a reduced phosphocreatine (PCr) and an increased calculated free adenosine diphosphate (ADP) in the occipital lobes of all patients. In our patients with PSP, inorganic phosphate (Pi) was significantly increased and Mg 2+ was reduced. In the gastrocnemius muscle, Pi at rest was increased in four patients, and the three patients who were able to perform an incremental exercise showed a rate of PCr post‐exercise recovery slower than control subjects. Our findings show that multisystemic deficit of energy metabolism occurs in PSP and suggest that it may play a role in the pathogenesis of this disorder.