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Decrease in presynaptic inhibition on heteronymous monosynaptic Ia terminals in patients with Parkinson's disease
Author(s) -
Morita Hiroshi,
Shindo Masaomi,
Ikeda Shuichi,
Yanagisawa Nobuo
Publication year - 2000
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200009)15:5<830::aid-mds1011>3.0.co;2-e
Subject(s) - facilitation , parkinson's disease , physical medicine and rehabilitation , neuroscience , medicine , disease , psychology , gait , physical therapy
PURPOSE Heteronymous Ia facilitation from the quadriceps to the soleus was studied to clarify central motor control through presynaptic inhibition (PSI) on Ia terminals of spinal motoneurons in Parkinson's disease. METHODS 17 patients with Parkinson's disease and 36 control subjects participated in the study. Because the early part of facilitation reflects the degree of PSI, the extent of facilitation was quantified as the slope, within 0.8 msec of onset. RESULTS Heteronymous Ia facilitation in the patients was greater than in the age‐matched control participants. PSI was negatively correlated with the walking speed of the patients. In the patients examined twice, lessening of bradykinesia was correlated to a decrease in PSI but not lessening of rigidity. CONCLUSION These findings indicate that the degree of PSI is decreased and disturbance of the central control of PSI may relate to gait disturbance in Parkinson's disease.