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The pathogenesis of multiple system atrophy: Past, present, and future
Author(s) -
Jaros Evelyn,
Burn David J.
Publication year - 2000
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200009)15:5<784::aid-mds1004>3.0.co;2-p
Subject(s) - atrophy , pathogenesis , disease , pathology , neuroscience , dementia with lewy bodies , alpha synuclein , dementia , etiology , medicine , parkinson's disease , biology
Multiple system atrophy is a sporadic, adult‐onset neurodegenerative disease of unknown etiology. The condition may be unique among neurodegenerative diseases by the prominent, if not primary, role played by the oligodendroglial cell in the pathogenetic process. Recent developments in our understanding of multiple system atrophy have included the detection of glial cytoplasmic inclusions and α‐synuclein accumulation in these inclusions. The latter finding links multiple system atrophy as an “α‐synucleinopathy” to Parkinson's disease and dementia with Lewy bodies. This article reviews recent important findings of potential relevance to the pathogenesis of multiple system atrophy. We also speculate on areas in which further advances may be made to progress our understanding of this devastating condition.