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Progressive multifocal leukoencephalopathy presenting with an isolated focal movement disorder
Author(s) -
Stockhammer Günther,
Poewe Werner,
Wissel Jórg,
Kiechl Ursula,
Maier Hans,
Felber Stefan
Publication year - 2000
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200009)15:5<1006::aid-mds1038>3.0.co;2-5
Subject(s) - progressive multifocal leukoencephalopathy , papovavirus , slow virus , jc virus , medicine , movement disorders , pathology , central nervous system disease , neurological disorder , central nervous system , disease , surgery , multiple sclerosis , virus , immunology
Progressive multifocal leukoencephalopathy (PML) is a rare but fatal papovavirus infection of the central nervous system predominantly affecting immunocompromised patients. Although the basal ganglia circuitry may be involved in the pathology of PML, movement disorders are exceedingly rare as presenting symptoms and have not been described as isolated features in such patients. We report a previously healthy, immunocompetent 24‐year‐old woman with histologically proven PML who presented with a focal movement disorder of the left arm as an isolated symptom for many months before diagnosis.