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Early detection of probable idiopathic Parkinson's disease: I. development of a diagnostic test battery
Author(s) -
Montgomery Erwin B.,
Koller William C.,
LaMantia Theodora J. K.,
Newman Mary C.,
SwansonHyland Elizabeth,
Kaszniak Alfred W.,
Lyons Kelly
Publication year - 2000
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(200005)15:3<467::aid-mds1007>3.0.co;2-#
Subject(s) - receiver operating characteristic , audiology , physical medicine and rehabilitation , psychology , parkinson's disease , mood , medicine , disease , psychiatry
We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion‐and‐extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.