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Bradykinesia and impairment of EEG desynchronization in Parkinson's disease
Author(s) -
Brown Peter,
Marsden C. David
Publication year - 1999
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/1531-8257(199905)14:3<423::aid-mds1006>3.0.co;2-v
Subject(s) - electroencephalography , parkinson's disease , physical medicine and rehabilitation , neuroscience , medicine , degenerative disease , disease , audiology , psychology , central nervous system disease
It has been suggested that the basal ganglia control the release of cortical elements from low‐frequency rhythmic idling activity during voluntary movement. 1 This hypothesis was tested by recording the local idling rhythms of the motor cortex, the alpha and beta rhythms, in 12 untreated and treated patients with Parkinson's disease as they moved a wrist. Recordings were made after overnight withdrawal of medication and again 1 hr after levodopa. The treatment‐related attenuation of the alpha and beta rhythms picked up over the cortical motor areas contralateral to the active arm correlated with the improvement in size and speed of movement effected by levodopa. The distribution and degree of attenuation depended on the complexity of the task. These results demonstrate for the first time a specific effect of levodopa on the organization of motor cortical activity in the frequency domain, an effect that correlates with improvements in bradykinesia.