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14‐3‐3 Protein cerebrospinal fluid detection in human growth hormone–treated Creutzfeldt‐Jakob disease patients
Author(s) -
Brandel JeanPhilippe,
Peoc'h Katell,
Beaudry Patrice,
Welaratne Arlette,
Bottos Corinne,
Agid Yves,
Laplanche JeanLouis
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(20010201)49:2<257::aid-ana48>3.0.co;2-x
Subject(s) - cerebrospinal fluid , prnp , creutzfeldt jakob syndrome , disease , medicine , prion protein , dementia , human growth hormone , hormone , genotype , growth hormone , pathology , biology , gene , genetics
The usefulness of the detection of 14‐3‐3 protein in the cerebrospinal fluid (CSF) in the diagnosis of Creutzfeldt‐Jakob disease transmitted from human growth hormone was evaluated in 20 French patients. The 14‐3‐3 protein was rarely detectable within the first 3 months of the disease but always positive after 7 months associated with the aggravation of the disease and the occurrence of dementia. 14‐3‐3 detection was not predictive of the survival time of the patients. The genotype at PRNP codon 129 could influence the timing of appearance of the 14‐3‐3 protein in the CSF. Ann Neurol 2001;49:257–260