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Anti‐Yo antibodies and cerebellar degeneration in a man with adenocarcinoma of the esophagus
Author(s) -
Sutton Ian J.,
Fursdon Davis Christopher J.,
Esiri Margaret M.,
Hughes Sharon,
Amyes Elisabeth R.,
Vincent Angela
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(20010201)49:2<253::aid-ana47>3.0.co;2-3
Subject(s) - esophagus , degeneration (medical) , paraneoplastic cerebellar degeneration , cerebellar degeneration , medicine , antibody , pathology , adenocarcinoma , cerebellum , immunology , autoantibody , cancer
Serum antibodies to the Yo antigen are usually associated with paraneoplastic cerebellar degeneration arising in female patients with gynecological or breast malignancy and are rarely associated with other tumors. We report a male patient who presented with paraneoplastic cerebellar degeneration and anti‐Yo antibodies following removal of an esophageal adenocarcinoma. This is only the third report of anti‐Yo antibodies occurring in a male patient. The Yo antigen was expressed by the esophageal tumor but not in a frontal lobe cerebral metastasis identified at postmortem. Interestingly, CD8 + T‐cell infiltration was also found in the tumor, but not in the metastasis, consistent with down‐regulation of Yo expression by the tumor cells leading to evasion from immune‐mediated tumor surveillance. Ann Neurol 2001;49:253–257