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Functional correlates of pallidal stimulation for Parkinson's disease
Author(s) -
Fukuda Masafumi,
Mentis Marc,
Ghilardi Maria Felice,
Dhawan Vijay,
Antonini Angelo,
Hammerstad John,
Lozano Andres M.,
Lang Anthony,
Lyons Kelly,
Koller William,
Ghez Claude,
Eidelberg David
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(20010201)49:2<155::aid-ana35>3.0.co;2-9
Subject(s) - globus pallidus , cerebral blood flow , deep brain stimulation , neuroscience , motor cortex , supplementary motor area , psychology , stimulation , thalamus , parkinson's disease , cerebral cortex , medicine , basal ganglia , functional magnetic resonance imaging , central nervous system , cardiology , disease
We measured regional cerebral blood flow with H 2 15 O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. Six right‐handed patients with Parkinson's disease were scanned while performing a predictable paced sequence of reaching movements and while observing the same screen displays and tones. PET studies were performed ON and OFF stimulation in a medication‐free state. Internal globus pallidus deep brain stimulation improved off‐state United Parkinson's Disease Rating Scale motor ratings (37%, p < 0.002) and reduced timing errors (movement onset time, 55%, p < 0.01) as well as spatial errors (10%, p < 0.02). Concurrent regional cerebral blood flow recordings revealed a significant enhancement of motor activation responses in the left sensorimotor cortex (Brodmann area [BA] 4), bilaterally in the supplementary motor area (BA 6), and in the right anterior cingulate cortex (BA 24/32). Significant correlations were evident between the improvement in motor performance and the regional cerebral blood flow changes mediated by stimulation. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebellum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selectively improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention. Ann Neurol 2001:49:155–164