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Herpes simplex virus type 1 (HSV‐1)–induced retinitis following herpes simplex encephalitis: Indications for brain‐to‐eye transmission of HSV‐1
Author(s) -
Maertzdorf Jeroen,
Van Der Lelij Allegonda,
Seerp Baarsma G.,
Osterhaus Albert D. M. E.,
Verjans Georges M. G. M.
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200012)48:6<936::aid-ana16>3.0.co;2-7
Subject(s) - herpes simplex virus , encephalitis , acute retinal necrosis , medicine , virology , retinitis , hsl and hsv , transmission (telecommunications) , herpesviridae , alphaherpesvirinae , immunology , virus , viral disease , human cytomegalovirus , electrical engineering , engineering
Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV‐1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV‐1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV‐1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain‐to‐eye transmission of HSV‐1 in these patients. Ann Neurol 2000;48:936–939