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Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA‐G
Author(s) -
Wiendl Heinz,
Behrens Lueder,
Maier Sabine,
Johnson Margaret A.,
Weiss Elisabeth H.,
Hohlfeld Reinhard
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200010)48:4<679::aid-ana19>3.0.co;2-v
Subject(s) - major histocompatibility complex , human leukocyte antigen , immunology , antigen , myocyte , histocompatibility , downregulation and upregulation , gene isoform , immune system , biology , transplantation , interferon , gene , medicine , microbiology and biotechnology , genetics
We demonstrate that HLA‐G, a nonclassical major histocompatibility complex class I antigen, is expressed in muscle fibers in various inflammatory myopathies. Further, interferon‐γ induces surface expression and upregulation of mRNA transcripts corresponding to different isoforms of HLA‐G in myoblasts cultured from control subjects and patients. HLA‐G may have important immunological functions in inflammatory myopathies and other local immune reactions as they occur during vaccination, myoblast transplantation, and gene therapy. Ann Neurol 2000;48:679–684