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Acquired hippocampal damage after temporal lobe seizures in 2 infants
Author(s) -
Roulet Perez Eliane,
Maeder Philippe,
Meagher Villemure Kathleen,
Chaves Vischer Virgini,
Villemure JeanGuy,
Deonna Thierry
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200009)48:3<384::aid-ana15>3.0.co;2-n
Subject(s) - hippocampal formation , status epilepticus , hippocampal sclerosis , temporal lobe , magnetic resonance imaging , hippocampus , medicine , pathological , neuroimaging , encephalitis , pathology , epilepsy , neuroscience , psychology , radiology , virus , virology
Two infants developed unilateral hippocampal swelling on magnetic resonance imaging after prolonged seizures of temporal origin. Subsequent images suggested hippocampal sclerosis. The first child had febrile status epilepticus with exanthem subitum and developed refractory complex partial seizures. Histological findings after temporal lobectomy confirmed hippocampal sclerosis but also revealed sequelae of a focal encephalitis and microdysgenesis of the hippocampus. The second child had signs of brain dysgenesis, but acquired hippocampal damage affecting each side successively was documented by serial magnetic resonance imaging. These cases illustrate that different clinical conditions combining preexisting and acquired pathological characteristics can lead to hippocampal sclerosis. Ann Neurol 2000;48:384–387