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No tissue damage by chronic deep brain stimulation in Parkinson's disease
Author(s) -
Haberler Christine,
Alesch François,
Mazal Peter R.,
Pilz Peter,
Jellinger Kurt,
Pinter Michaela M.,
Hainfellner Johannes A.,
Budka Herbert
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200009)48:3<372::aid-ana12>3.0.co;2-0
Subject(s) - deep brain stimulation , gliosis , subthalamic nucleus , parkinson's disease , medicine , pathological , parenchyma , neuroscience , stimulation , pathology , disease , psychology
We report on the pathological findings in the brains of 8 Parkinson's disease patients treated with deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (6 cases) and subthalamic nucleus (2 cases). DBS was performed continuously for up to 70 months. All brains showed well‐preserved neural parenchyma and only mild gliosis around the lead track compatible with reactive changes due to surgical placement of the electrode. We conclude that chronic DBS does not cause damage to adjacent brain tissue. Ann Neurol 2000;48:372–376