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Myelin widenings and MGUS‐IgA: An immunoelectron microscopic study
Author(s) -
Vallat JeanMichel,
Tabaraud François,
Sindou Philippe,
Preux PierreMarie,
Vandenberghe Antoon,
Steck Andreas
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200006)47:6<808::aid-ana15>3.0.co;2-8
Subject(s) - immunoelectron microscopy , myelin , pathology , polyneuropathy , monoclonal , myelin associated glycoprotein , monoclonal antibody , electron microscope , myelin sheath , medicine , immunohistochemistry , immunology , antibody , central nervous system , physics , optics
A few studies have reported a variety of nonspecific histological lesions in patients with IgA monoclonal gammopathies and polyneuropathy. In our case, using electron microscopy, we observed widenings of the myelin lamellae identical to those commonly described in IgM neuropathies with anti–myelin‐associated glycoprotein activity. Using immunoelectron microscopy, we demonstrated a direct involvement of IgA in myelin lesions. The search for a direct link between monoclonal dysglobulinemia, regardless of type, and polyneuropathy is important and may influence treatment. Ann Neurol 2000;47:808–811