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Decreased cerebrospinal fluid levels of β‐phenylethylamine in patients with Rett syndrome
Author(s) -
Satoi Mika,
Matsuishi Toyojiro,
Yamada Shigeto,
Yamashita Yushiro,
Ohtaki Etsuo,
Mori Kenji,
Riikonen Raili,
Kato Hirohisa,
Percy Alan K.
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200006)47:6<801::aid-ana13>3.0.co;2-l
Subject(s) - rett syndrome , cerebrospinal fluid , medicine , dopamine , degenerative disease , endocrinology , central nervous system disease , psychology , biology , biochemistry , gene
To clarify the mechanism of brain impairment in Rett syndrome, we measured the cerebrospinal fluid levels of β‐phenylethylamine (PEA) in 17 patients with Rett syndrome. Findings were compared with those obtained in age‐matched controls and diseased controls. The cerebrospinal fluid level of PEA was significantly lower in patients with Rett syndrome than in the controls (31% of control values). The alteration in the cerebrospinal fluid level of PEA may reflect dopamine system impairment in Rett syndrome. Ann Neurol 2000;47:801–803