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The role of B cells and autoantibodies in multiple sclerosis
Author(s) -
Archelos Juan J.,
Storch Maria K.,
Hartung HansPeter
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200006)47:6<694::aid-ana2>3.0.co;2-w
Subject(s) - autoantibody , multiple sclerosis , pathogenesis , immunology , neuroscience , autoimmunity , antibody , biology , medicine
A variety of cellular and humoral immunological abnormalities have been observed in multiple sclerosis (MS). In the past few years, several lines of evidence converged to imply an important role of autoreactive antibodies and B cells in the pathogenesis of MS. Recent data suggest that autoantibodies may be harmful in lesion formation but also potentially beneficial in repair. This review surveys recent advances in the concepts of generation and nature of pathogenetic autoantibodies, their potential modes of action, mechanisms of their long‐term persistence, and the role of the inflamed brain tissue as a B‐cell–supporting microenvironment in MS. Based on the presence of specific autoantibodies, it seems possible to define distinct MS subgroups in the near future. The therapeutic relevance of these new findings is presented. Ann Neurol 2000;47:694–706