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Glutamate uptake is decreased in platelets from Alzheimer's disease patients
Author(s) -
Ferrarese Carlo,
Begni Barbara,
Canevari Carla,
Zoia Chiara,
Piolti Roberto,
Frigo Maura,
Appollonio Ildebrando,
Frattola Lodovico
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200005)47:5<641::aid-ana12>3.0.co;2-i
Subject(s) - excitotoxicity , glutamate receptor , glutamatergic , platelet , neurodegeneration , dementia , disease , alzheimer's disease , medicine , degenerative disease , neuroscience , psychology , receptor
Because excitotoxicity may be involved in neurodegeneration in Alzheimer's disease, we investigated possible modifications of platelet glutamate uptake in AD patients. High‐affinity glutamate uptake was studied in platelets from 35 Alzheimer's disease patients, 10 multi‐infarct dementia patients, and 35 age‐matched normal controls; it was decreased by 40% in platelets from Alzheimer's disease patients compared with controls and with multi‐infarct dementia patients. Platelet glutamate uptake could be used as peripheral marker of glutamatergic involvement and as adjunctive diagnostic tool in Alzheimer's disease patients. Ann Neurol 2000;47:641–643