Premium
Synphilin‐1 is present in Lewy bodies in Parkinson's disease
Author(s) -
Wakabayashi Koichi,
Engelender Simone,
Yoshimoto Makoto,
Tsuji Shoji,
Ross Christopher A.,
Takahashi Hitoshi
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200004)47:4<521::aid-ana18>3.0.co;2-b
Subject(s) - parkinson's disease , pathogenesis , synuclein , lewy body , disease , neuroscience , alpha synuclein , pathology , dementia with lewy bodies , medicine , biology , dementia
α‐Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α‐synuclein gene are responsible for familial forms of PD and α‐synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin‐1 is a novel protein that we have previously found to associate in vivo with α‐synuclein. We now show that synphilin‐1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin‐1 could play a role in Lewy body formation and the pathogenesis of PD. Ann Neurol 2000;47:521–523.