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Increased bone turnover in epileptic patients treated with carbamazepine
Author(s) -
Verrotti Alberto,
Greco Rita,
Morgese Guido,
Chiarelli Francesco
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200003)47:3<385::aid-ana18>3.0.co;2-w
Subject(s) - bone remodeling , endocrinology , carbamazepine , medicine , osteocalcin , type i collagen , bone resorption , n terminal telopeptide , procollagen peptidase , alkaline phosphatase , urine , epilepsy , chemistry , enzyme , biochemistry , psychiatry
Bone turnover has been investigated in 12 epileptic patients before and after treatment with carbamazepine and in 15 sex‐ and age‐matched control subjects. We found higher values of markers of bone formation (serum bone alkaline phosphatase, osteocalcin, and propeptides of types I and III procollagen) and of bone resorption (serum telopeptide of type I collagen and urine N‐telopeptides of type I collagen) in patients than in controls. Our study demonstrates that carbamazepine induces an increase of bone turnover. Ann Neurol 2000;47:385–388