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Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy
Author(s) -
Di Maria Emilio,
Tabaton Massimo,
Vigo Tiziana,
Abbruzzese Giovanni,
Bellone Emilia,
Donati Catia,
Frasson Emma,
Marchese Roberta,
Montagna Pasquale,
Munoz David G.,
Pramstaller Peter P.,
Zanusso Gianluigi,
Ajmar Franco,
Mandich Paola
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200003)47:3<374::aid-ana15>3.0.co;2-8
Subject(s) - progressive supranuclear palsy , corticobasal degeneration , tauopathy , neuroscience , haplotype , pathology , pathological , medicine , psychology , biology , neurodegeneration , genetics , allele , gene , disease
Corticobasal degeneration is a sporadic form of tauopathy, involving the cerebral cortex and extrapyramidal motor system. A series of affected subjects was genotyped for a set of genetic markers along the tau protein gene. A specific haplotype is significantly overrepresented in patients versus controls. This haplotype is the same already reported in association with progressive supranuclear palsy. These data show that corticobasal degeneration and progressive supranuclear palsy, in addition to several clinical, pathological, and molecular features, may have the same genetic background. Ann Neurol 2000;47:374–377