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Association of interleukin‐1 gene polymorphisms with Alzheimer's disease
Author(s) -
Nicoll James A. R.,
Mrak Robert E.,
Graham David I.,
Stewart Janice,
Wilcock Gordon,
MacGowan Sian,
Esiri Margaret M.,
Murray Lilian S.,
Dewar Deborah,
Love Seth,
Moss Tim,
Griffin W. Sue T.
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200003)47:3<365::aid-ana13>3.0.co;2-g
Subject(s) - apolipoprotein e , genotype , odds ratio , allele , disease , alzheimer's disease , medicine , degenerative disease , risk factor , interleukin , immunology , genetics , biology , gene , cytokine
Interleukin‐1 (IL‐1) is markedly overexpressed in Alzheimer's disease. We found the IL‐1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL‐1A and allele 2 of IL‐1B conferred even greater risk (odds ratio, 10.8). IL‐1 genotypes may confer risk for Alzheimer's disease through IL‐1 overexpression and IL‐1–driven neurodegenerative cascades. Ann Neurol 2000;47:365–368