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Specific changes in somatosensory evoked magnetic fields during recovery from sensorimotor stroke
Author(s) -
Wikström Heidi,
Roine Risto O.,
Aronen Hannu J.,
Salonen Oili,
Sinkkonen Janne,
Ilmoniemi Risto J.,
Huttunen Juha
Publication year - 2000
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(200003)47:3<353::aid-ana11>3.0.co;2-r
Subject(s) - somatosensory system , somatosensory evoked potential , sensory system , stimulation , stroke (engine) , neuroscience , medicine , median nerve , transcranial magnetic stimulation , audiology , psychology , anatomy , physics , thermodynamics
We studied recovery‐induced changes in the responsiveness of the primary somatosensory cortex in stroke patients with sensory and/or motor symptoms. Somatosensory evoked magnetic fields, in response to median nerve stimulation, were recorded in 14 patients with their first symptomatic unilateral stroke 1 to 15 days from the first symptoms and again 2 to 3 months later. Neuronal activity at the contralateral primary somatosensory cortex was modeled with equivalent current dipoles at the peak latencies of the first two cortical deflections at about 20 msec (N1m) and at 28 to 91 msec (P1m). Twenty‐three age‐matched healthy volunteers, 9 of whom were tested also in serial recordings, served as control subjects. At follow‐up, 6 patients showed a significant increase of P1m amplitude, whereas N1m increased only in 1. Clinical improvement of two‐point discrimination ability, but not of other basic somatosensory skills, was significantly correlated with the increase of P1m. We conclude that the recovery of discriminative touch after stroke is paralleled by the growth of the P1m somatosensory evoked magnetic field deflection, and we propose that this may reflect re‐establishment of lateral inhibitory functions at the primary somatosensory cortex. Ann Neurol 2000;47:353–360