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Increased 8‐oxo‐dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease
Author(s) -
ShimuraMiura Hideki,
Hattori Nobutaka,
Kang Dongchon,
Miyako KenIchi,
Nakabeppu Yusaku,
Mizuno Yoshikuni
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199912)46:6<920::aid-ana17>3.0.co;2-r
Subject(s) - substantia nigra , oxidative stress , mitochondrion , parkinson's disease , oxidative phosphorylation , disease , biology , respiratory chain , neuroscience , medicine , biochemistry
There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8‐oxo‐dGTPase (8‐oxo‐7, 8‐dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8‐oxo‐7, 8‐deoxyguanosine (8‐oxo‐dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a useful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.