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Olfactory bulb dysplasia: A novel subtype of neuronal migration disorder
Author(s) -
Yamanouchi Hideo,
Hirato Junko,
Yokoo Hideaki,
Nako Yasushi,
Morikawa Akihiro,
Nakazato Yoichi
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199911)46:5<783::aid-ana16>3.0.co;2-f
Subject(s) - olfactory bulb , granule cell , laminar organization , reticular connective tissue , biology , anatomy , neuroscience , dysplasia , pathology , granular layer , olfactory system , dentate gyrus , cerebellum , central nervous system , medicine , genetics
We present a novel subtype of neuronal migration disorder found in a case of Pena‐Shokeir phenotype, in which the deformation sequence originated from neurogenic fetal akinesia. The autopsied brain showed dysplastic features of dentate and olivary nuclei as well as a bilaterally enlarged olfactory bulb with abnormal laminar structures. The laminar structures comprised four layers: (1) a superficial layer without glomeruli, (2) a neuronal cell layer containing neurons simulating mitral cells, (3) a sparse cell layer enriched with tangential neuronal fibers, and (4) a reticular layer showing a mottled appearance with the accumulation of fine reticular neurites intermingled with granule cells. To our knowledge, these malformed laminar changes have never been reported, and we propose the term olfactory bulb dysplasia.