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Intraventricular transplantation of oligodendrocyte progenitors into a fetal myelin mutant results in widespread formation of myelin
Author(s) -
Learish Randall D.,
Brüstle Oliver,
Zhang SuChun,
Duncan Ian D.
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199911)46:5<716::aid-ana6>3.0.co;2-m
Subject(s) - myelin , transplantation , oligodendrocyte , progenitor cell , biology , multiple sclerosis , white matter , corpus callosum , pathology , embryonic stem cell , stem cell , microbiology and biotechnology , neuroscience , immunology , central nervous system , medicine , genetics , gene , radiology , magnetic resonance imaging
Transplantation of myelin‐forming cells is a promising strategy for the treatment of myelin disorders. In this study, transplantation of glial cell progenitors into the cerebral ventricles of the embryonic myelin‐deficient rat, a model of Pelizaeus‐Merzbacher disease, was performed to assess the ability of these cells to incorporate into the developing brain and produce myelin. The donor cells migrated into the white and gray matter and produced myelin at widespread sites ranging from the corpus callosum and optic nerve to the cerebellum. These data suggest that myelin repair might be achieved by intraventricular delivery and transependymal incorporation of myelin‐producing cells. Because these cells were genetically transduced to express a reporter gene, similar ex vivo manipulation with genes known to promote survival, migration, or proliferation of the transplanted cells could be used to enhance repair. Such a therapeutic strategy may be feasible in patients with inherited myelin disorders or in multiple sclerosis, particularly where the lesions are periventricular.