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Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease
Author(s) -
Ojaimi Joseline,
Masters Colin L.,
McLean Catriona,
Opeskin Ken,
McKelvie Penny,
Byrne Edward
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199910)46:4<656::aid-ana16>3.0.co;2-q
Subject(s) - cytochrome c oxidase , protein subunit , alzheimer's disease , disease , degenerative disease , cerebellum , biology , medicine , endocrinology , neuroscience , enzyme , biochemistry , gene
This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age‐matched controls relative to young controls and in the Alzheimer's disease group relative to both age‐matched and young controls. Results suggest that these age‐associated changes are more marked in Alzheimer's disease.