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Language area localization with three‐dimensional functional magnetic resonance imaging matches intrasulcal electrostimulation in Broca's area
Author(s) -
Rutten G. J. M.,
Van Rijen P. C.,
Van Veelen C. W. M.,
Ramsey N. F.
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199909)46:3<405::aid-ana17>3.0.co;2-g
Subject(s) - broca's area , functional magnetic resonance imaging , magnetic resonance imaging , inferior frontal gyrus , brain mapping , neuroscience , psychology , epilepsy surgery , epilepsy , medicine , radiology
In this study, intraoperative electrocortical stimulation mapping (ioESM), the current gold standard for the localization of critical language areas, is compared with functional magnetic resonance imaging (fMRI) in a 14‐year‐old girl with medically intractable epilepsy caused by a tumor in the region of Broca's area. Prior to the operation, four different fMRI tasks that target inferior frontal language areas were applied. Prior to the resection, ioESM as well as fMRI detected no language areas at the exposed cortical area. After removal of the tumor, a unique opportunity presented itself, where ioESM could be performed in the depth of a now exposed and intact gyrus. One specific locus that was indicated to be a critical language area by multiple‐task fMRI was targeted. IoESM selectively confirmed the location of this language area to within an estimated 3 mm. We propose that the combined use of different fMRI tasks increases the sensitivity and specificity for the detection of essential language areas.