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Phosphorus and proton magnetic resonance spectroscopy in episodic ataxia type 2
Author(s) -
SappeyMarinier Dominique,
Vighetto Alain,
Peyron Roland,
Broussolle Emmanuel,
Bonmartin Alain
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199908)46:2<256::aid-ana17>3.0.co;2-6
Subject(s) - proton magnetic resonance , nuclear magnetic resonance , ataxia , cerebrum , chemistry , cerebellum , nuclear magnetic resonance spectroscopy , magnetic resonance imaging , spectroscopy , endocrinology , medicine , central nervous system , psychiatry , physics , quantum mechanics , radiology
Localized phosphorus ( 31 P) and proton ( 1 H) magnetic resonance spectroscopy was performed in the cerebellum and the occipital lobe of 6 patients with episodic ataxia type 2. From use of 31 P magnetic resonance spectroscopy, untreated patients showed decreased high‐energy phosphate ratios in the cerebrum, and increased pH in the cerebellum and cerebrum, which normalized under acetazolamide. 1 H magnetic resonance spectra demonstrated high lactate peaks in 3 of the 6 patients. These metabolic alterations, probably induced by the calcium channelopathy, may characterize episodic ataxia type 2. Ann Neurol 1999;46:256–259