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Function of the cerebellum in parkinsonian rest tremor and Holmes' tremor
Author(s) -
Deuschl G.,
Wilms H.,
Krack P.,
Würker M.,
Heiss W.D.
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199907)46:1<126::aid-ana20>3.0.co;2-3
Subject(s) - cerebellum , resting tremor , parkinson's disease , rest (music) , postural tremor , essential tremor , physical medicine and rehabilitation , medicine , midbrain , neuroscience , psychology , disease , central nervous system , pathology , cardiology
We describe a patient who developed Parkinson's disease (PD) 17 years after resection of his right cerebellum because of a Lindau tumor. He showed a classic 4.3‐Hz resting tremor on the left side but a 3.1‐Hz resting, postural, and intention tremor on the right side compatible with midbrain tremor (Holmes' tremor). We conclude that the generator of the tremor in PD cannot be located within the olivocerebellar loop. The cerebellum, however, seems to modulate the tremor frequency of parkinsonian rest tremor and may prevent the rest tremor from transforming into a postural and goal‐directed tremor. Ann Neurol 1999;46:126–128