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The postmigrational development of polymicrogyria documented by magnetic resonance imaging from 31 weeks' postconceptional age
Author(s) -
Inder Terrie E.,
Huppi Petra S.,
Zientara Gary P.,
Vjolesz Ferenc A.,
Holling Erik E.,
Robertson Richard,
Barnes Patrick D.,
Volpe Joseph J.
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199906)45:6<798::aid-ana16>3.0.co;2-u
Subject(s) - polymicrogyria , magnetic resonance imaging , medicine , radiology
We report the case of a 27‐week premature infant in whom magnetic resonance imaging (MRI) at 4 postnatal weeks (postconceptional age, 31 weeks), term, and 6 months of age documented the postnatal postmigrational evolution of bilateral perisylvian polymicrogyria. The polymicrogyria was readily detected by ultrafine 1.5‐mm coronal slices on three‐dimensional, Fourier‐transformed, spoiled gradient–recalled and T2‐weighted MRI sequences. These MRI sequences provide the first in vivo documentation of the postmigrational evolution of polymicrogyria. The likelihood that the polymicrogyria was related to an ischemic encephaloclastic mechanism is supported by the simultaneous occurrence of periventricular leukomalacia. Ann Neurol 1999;45:798–801