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Development of amino acid receptors in frontal cortex from girls with Rett syndrome
Author(s) -
Blue Mary E.,
Naidu Sakkubai,
Johnston Michael V.
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199904)45:4<541::aid-ana21>3.0.co;2-2
Subject(s) - rett syndrome , frontal cortex , neuroscience , psychology , receptor , developmental psychology , biology , medicine , biochemistry , gene
To determine whether a disorder of excitatory neurotransmission plays a role in the pathophysiology of Rett syndrome (RS), N ‐methyl‐ D ‐aspartate (NMDA), adenosine monophosphate acid (AMPA), kainate, and metabotropic types of glutamate receptors were labeled autoradiographically in the superior frontal gyrus (SFG) from 9 RS patients and 10 female controls. The results showed a trend for the densities of NMDA, AMPA, gamma‐aminobutyric acid, and metabotropic glutamate receptors to be higher in younger patients than in controls and for densities in older patients to fall below those of controls. The age‐related changes in SFG NMDA receptor density may be correlated with the shift from psychomotor regression and seizures in younger stage II/III RS girls to the less epileptic plateau stage in older girls. Ann Neurol 1999;45:541–545