Premium
Lipoprotein‐free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome
Author(s) -
Matsubara Etsuro,
Ghiso Jorge,
Frangione Blas,
Amari Masakuni,
Tomidokoro Yasushi,
Ikeda Yoshio,
Harigaya Yasuo,
Okamoto Koichi,
Shoji Mikio
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199904)45:4<537::aid-ana20>3.0.co;2-2
Subject(s) - medicine , endocrinology , lipoprotein , alzheimer's disease , disease , amyloid beta , amyloid (mycology) , cholesterol , pathology
About 90% of the soluble amyloid β (sAβ) that circulates in normal human plasma is associated with lipoprotein particles. In sporadic Alzheimer's disease patients, free sAβ42 but not sAβ40 is increased approximately 2.3‐fold compared with age‐matched controls, although a more marked elevation (approximately 8‐fold for free sAβ40 and about 20‐fold for sAβ42) is found in Down's syndrome patients. The data suggest that lipoprotein‐sAβ dissociation may contribute to the influx of sAβ into the brain as a result of decreased plasma clearance. Ann Neurol 1999;45:537–541