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Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy
Author(s) -
O'Brien Terence J.,
So Elson L.,
Meyer Fredrick B.,
Parisi Joseph E.,
Jack Clifford R.
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199904)45:4<526::aid-ana17>3.0.co;2-n
Subject(s) - temporal lobe , epilepsy , atrophy , hippocampal formation , neuroscience , intractable epilepsy , medicine , hippocampus , psychology , pathology
We report on a 28‐year‐old man with long‐standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow‐up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus. Ann Neurol 1999;45:526–529