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Radiation‐induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma
Author(s) -
Grill J.,
Couanet D.,
Cappelli C.,
Habrand J. L.,
Rodriguez D.,
SainteRose C.,
Kalifa C.
Publication year - 1999
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/1531-8249(199903)45:3<393::aid-ana17>3.0.co;2-b
Subject(s) - medicine , neurofibromatosis , radiation therapy , complication , glioma , radiological weapon , optic nerve , radiology , surgery , ophthalmology , cancer research
Occlusive vasculopathy is a potential complication of radiotherapy in children with optic pathway glioma. With a median follow‐up of 7 years, 13 of 69 children in this study developed clinical and radiological signs of occlusive vasculopathy after radiotherapy within a median interval of 36 months. The major risk factor was neurofibromatosis type 1. Radiotherapy should no longer be the first treatment in these settings. When radiotherapy is unavoidable, regular screening for cerebral vasculopathy is mandatory, as preventive treatment is available. Ann Neurol 1999;45:393–396