Open AccessMulticentric reticulohistiocytosis: Case report with immunohistochemical analysis and literature review
Author(s) -
Gorman Jennifer D.,
Danning Carol,
Schumacher H. Ralph,
Klippel John H.,
Davis John C.
Publication year - 2000
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/1529-0131(200004)43:4<930::aid-anr27>3.0.co;2-a
Subject(s) - medicine , pathology , immunohistochemistry , pathogenesis , monocyte , macrophage , disease , immunology , biology , biochemistry , in vitro
This report describes the case of a patient with multicentric reticulohistiocytosis. Immunohistochemical analysis revealed prominent markers of monocyte/macrophage origin, as well as the presence of tumor necrosis factor α, interleukin‐1β (IL‐1β), and IL‐12; the occurrence of the latter in this disease has not previously been reported. Clinical, laboratory, radiographic, and histologic findings in multicentric reticulohistiocytosis are reviewed. In addition, all published cases of multicentric reticulohistiocytosis which included reports of cytokine and immunohistochemical analysis are reviewed, and evidence for a monocyte/macrophage origin and role in disease pathogenesis is provided.